DIM וכימותרפיה

גובי שלום אני סובלת מסרטן השד רגיש לאסטרוגן ומטופלת בטמוקסיפן. החלטתי להוסיף תוסף מזון DIM שידוע שיש לו פעילות דומה לטמוקסיפן. אולם אצלך בספר קראתי שלא מומלץ ליטול אותו במהלך כימותרפיה. האם מדובר בחומרים כיותרפיים ספציפיים או זו המלצה גורפת לכולם? תודה!

שלום ציונה, טמוקסיפן אינה תרופה כימותרפית אלא הורמונלית (אנטי-אסטרוגנית). ניתן ואף רצוי לשלב דים או אינדול-3-קרבינול עם טמוקסיפן. בברכה, גובי www.cure-cancer-naturally.com ******************************************************************************************* Vitamin Research Products writes: Breast Cancer The potent, anticarcinogen effects of I3C have been documented in a number of studies. Researchers at the University of California at Berkeley injected I3C directly into human breast cancer cells, then observed its effect on the cell cycle, the process by which cells divide. I3C halted the cell cycle process before it jumped into full gear, inhibiting the growth of the cancer cells AND preventing cell division by blocking DNA duplication.7 Due to its ability to halt the cell cycle, I3C is being looked upon as a possible adjunct therapy to breast cancer. For more than 20 years, the antiestrogen Tamoxifen has remained the drug of choice to treat breast cancer sufferers. But Tamoxifen has been a double-edged sword. Although it has extended the life of many women, only half of the two-thirds of breast cancer patients with estrogen dependent tumors respond to Tamoxifen therapy. Furthermore, after 12 - 18 months of treatment, users develop a resistance to the drug, AND it has been shown to stimulate the growth of breast cancer cells after prolonged use. 8-11 Research documents the effectiveness of combining I3C with Tamoxifen to eliminate the drugs potentially harmful effects AND to create an even more effective antiestrogen. University of California at Berkeley researchers injected three groups of human breast cancer cells, one group with I3C, another with Tamoxifen AND a third with the two substances combined. The cells injected with Tamoxifen alone experienced a 60 percent inhibition in DNA synthesis, while the cells injected with I3C experienced a 90 percent inhibition during the same time period. The combination of I3C AND Tamoxifen yielded a more effective suppression of the cancer cells than either substance alone, resulting in a 95 percent inhibition after 96 hours of treatment.12 Lower doses of Tamoxifen, when combined with I3C treatment, inhibited cancer cell growth to the same extent as higher doses of either substance added individually. These results indicate that patients on a combined Tamoxifen-I3C treatment program can substantially reduce their dosage of Tamoxifen, decreasing the likelihood of resistance to the drug.13 7. Cover CM, Hsieh SJ, Tran SH, Hallden G, Kim GS, Bjeldanes LF AND Firestone GL. Indole-3-carbinol inhibits the expression of cyclin-dependent kinase-6 AND induces a G1 cell cycle arrest of human breast cancer cells independent of estrogen receptor signaling. J Biol Chem. 1998; 273:3838-3847. 8. Legha SS. Tamoxifen in the treatment of breast cancer. Ann Intern Med. 1988; 109: 219-228. 9. Couillard S, Gutman M, Labrie C, Belanger A, Candas B AND Labrie F. Comparison of the effects of the antiestrogens EM-800 AND tamoxifen on the growth of human breast ZR-75-1 cancer xenografts in nude mice. Cancer Res. 1998; 58:60-64. 10. Gottardis MM AND Jordan VC. Development of tamoxifen-stimulated growth of MCF-7 tumors in athymic mice after long-term antiestrogen administration. Cancer Res. 1988; 48: 5183-5187. 11. Osborne CK, Coronado-Heinsohn EB, Hilsenbeck SG, McCue BL, Wakeling AE, McClelland RA, Manning DL, AND Nicholson RI. Comparison of the effects of a pure steroidal antiestrogen with those of tamoxifen in a model of human breast cancer. J Natl. Cancer Inst. 1995; 87:746-750. 12. Cover CM, Hsieh SJ, Cram EJ, Hong C, Riby JE, Bjeldanes LF, AND Firestone GL. Indole-3-carbinol AND tamoxifen cooperate to arrest the cell cycle of MCF-7 Human Breast Cancer Cells. Cancer Research. 1999; 59: 1244-1251. 13. Cover CM, Hsieh SJ, Cram EJ, Hong C, Riby JE, Bjeldanes LF, AND Firestone GL. Indole-3-carbinol AND tamoxifen cooperate to arrest the cell cycle of MCF-7 Human Breast Cancer Cells. Cancer Research. 1999; 59: 1244-1251. http://www.vrp.com/art/309.asp

גובי היקר , בנוסף לטמוקסיפן אני מקבלת טיפולים כימותרפיים עם אדריאמיצין וציספלטין ושאלתי אם יש התוויות נגד לשימוש עם תרופות אלו, ומה קורה עם תרופות כימותרפיות אחרות. אצלך בספר כתוב שאין להשתמש עם DIM יחד עם תרופות כימותרפיות ולכן אני מעוניינת לדעת אם זו איסור גורף לכל התרופות הכימותרפיות או כנגד תרופות ספציפיות? מודה לך שוב