selenium

שלום רב, האם קיימים מחקרים מדעיים על הסילניום והאם יש אפשרות להגן על הגוף בעזרת לקיחת הסילניום עם ויטמינים A ו - C מפני סרטן. בני חלה בהודג'קין והוא סיים טיפולי הקרנות. כדאי לתת לו תוספי מזון והאם הסילניום יכול לעזור לו בעתיד? תודה נורית

השורה התחתונה היא שאין כל המלצה רפואית לתוספת סלניום. יש כמה מאמרים הטוענים שאצל חולי סרטן, בין היתר מזכירים הודג'קין, יש רמה נמוכה של כמה יסודות, ביניהם סלניום. המאמרים אינם בעיתונים מהשורה הראשונה, מה שבד"כ מעיד על איכות המחקר. יש מאמרים מעיתונים יותר "רציניים" שלא מצאו קשר כזה. ראשית ראי את המחקרים התומכים: באתר של http://www.epa.gov מצאתי את המאמר הבא http://www.epa.gov/ttn/uatw/hlthef/selenium.html Clin Biochem 2000 Apr;33(3):209-12 Lipid peroxidation and antioxidant system in the blood of patients with Hodgkin's disease. Guven M, Ozturk B, Sayal A, Ozet A Department of Medical Biology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey. [email protected] OBJECTIVES: The purpose of this study was to measure the extent of lipid peroxidation and the status of antioxidants in patients with Hodgkin's disease.DESIGN AND METHODS: Glutathione peroxidase (GPX) and superoxide dismutase (SOD) activities, and malondialdehyde (MDA), selenium, zinc and copper content have been measured in 20 patients with Hodgkin's disease and 30 age-matched controls.RESULTS: Significantly higher concentrations of MDA in plasma as well as in erythrocytes were found compared to the control group. In both plasma and erythrocytes, GPX activity, selenium and zinc levels were significantly lower in patients than in controls. However, SOD activity in erythrocytes and copper levels in both plasma and erythrocytes were significantly higher in patients.CONCLUSION: We conclude that the antioxidant system is impaired in Hodgkin's disease due to the abnormal metabolism of trace elements and antioxidant enzymes. למרות כל אלה, עדיין אין שום הוכחה ברורה שאכן כך הדברים ואין המלצות טיפוליות לנטילת סלניום. יש גם דעות אחרות וממצאים אחרים: Tumori 2000 Mar-Apr;86(2):105-18 The epidemiology of selenium and human cancer. Vinceti M, Rovesti S, Bergomi M, Vivoli G Department of Hygiene, Microbiology & Biostatistics, University of Modena and Reggio Emilia, Modena, Italy. The relation between the trace element selenium and the etiology of cancer in humans remains elusive and intriguing, despite the number of epidemiologic studies published on the topic. We address some methodologic issues, such as misclassification of exposure, particularly to single selenium compounds, effect modification, confounding, and other sources of bias, which may explain the inconsistencies in the literature. We also review the results of cohort studies, which have yielded either inverse or null or direct associations between selenium exposure and subsequent cancer risk. To date, no beneficial effect on cancer incidence at major sites, including prostate cancer, has emerged from the Finnish program begun in 1984 to increase the average selenium intake in its population. Populations exposed to unusually high or low levels of environmental selenium might offer unique opportunities to investigate if selenium exposure is related to the etiology of human cancer. Haematologica 1995 Nov-Dec;80(6):505-11 Serum selenium concentrations in patients with newly diagnosed lymphoid malignancies. Avanzini P, Vinceti M, Ilariucci F, Masini L, D'Inca M, Vivoli G Divisione di Medicina Interna e Day-Hospital Ematologico, Arcispedale S. Maria Nuova, Reggio Emilia, Italy. BACKGROUND. Increased mortality from lymphoid malignancies following exposure to environmental selenium has recently been reported. Moreover, conflicting results have been found in investigations examining the relationship between serum concentrations of selenium and some clinical features of malignant lymphoproliferative diseases. METHODS. Serum concentrations of selenium were analyzed by atomic absorption spectrometry in fifty-nine patients with newly diagnosed chronic lymphoid malignancies and in forty control subjects. RESULTS. Selenium concentrations were significantly lower in patients than in control subjects. However, when only patients with localized disease were compared to controls, no significant difference in serum selenium concentrations was observed. Clinical stage was inversely associated with selenium levels. High-grade non-Hodgkin's lymphoma was characterized by lower selenium levels than low-grade and intermediate-grade disease. Selenium levels were positively associated with albumin and hemoglobin, and inversely correlated with serum concentrations of beta 2-microglobulin and with erythrocyte sedimentation rate. CONCLUSIONS. The findings of this study do not suggest that a high selenium intake represents a risk factor for malignant lymphoproliferative diseases, but limitations of the investigation hamper evaluation of the results. The possible utility of determining serum concentrations of selenium in the clinical evaluation of patients with lymphoid malignancies merits examination in larger studies. והנה מאמר מעיתון "רציני" שלא מצא תימוכין לתיאוריה זהו: J Clin Epidemiol 1995 Sep;48(9):1091-7 Cancer mortality in a residential cohort exposed to environmental selenium through drinking water. Vinceti M, Rovesti S, Gabrielli C, Marchesi C, Bergomi M, Martini M, Vivoli G Institute of Hygiene, University of Modena Medical School, Italy. Cancer mortality from 1986 to 1992 was examined in a cohort of 4419 individuals who had been residing in an area of the municipality of Reggio Emilia, northern Italy, where tap water with unusually high selenium content was accidentally supplied. Mortality for all cancers was not significantly different, both in males and in females, from that expected using death rates in the remaining municipal population as standard rates. No significant difference in mortality for site-specific cancers was observed in males, while in females a higher mortality for malignancies of the lymphatic-hematopoietic tissue overall considered and for non-Hodgkin's lymphoma was detected. Even if evaluation of the results is hampered by the low number of cancer deaths on which the analysis is based, findings of the study do not support the hypothesis of a strong inverse independent relationship between dietary intake of selenium and cancer mortality in humans. והנה עוד אחד שלא מצא הוכחה לטיעון: Scand J Haematol 1980 Jan;24(1):63-6 Serum selenium levels in malignant lymphoproliferative diseases. Calautti P, Moschini G, Stievano BM, Tomio L, Calzavara F, Perona G Serum selenium levels were measured in 38 patients with malignant lymphoproliferative diseases (MLD) and in 34 non-hospitalized healthy individuals. Selenium was determined by proton induced x-ray emission. In Hodgkin's disease and non-Hodgkin malignant lymphoma the mean serum levels of selenium were not different from those of the control group. On the contrary lowered mean serum selenium concentrations were observed in the group with chronic lymphocytic leukaemia (5.2 +/- 0.7 microgram/100 ml) as compared to normal individuals (7.9 +/- 0.3 microgram/100 ml). The difference is highly significant (P less than 0.005). A second selenium test was made in 11 out of the 38 patients within 8 weeks from the beginning of radiotherapy or chemotherapy; unchanged levels were found.