נוגדי דכאון

שלום רב, אני אמנם גבר, אך אני פונה אליכם (אולי לא בפורום המתאים לי) בשל המוניטין הרב שלכם בתחום הפוריות. אני נמצא במתח גדול מאחר שאשתי בשבוע התשיעי להריונה והיא נכנסה להריון בעודי נוטל ציפרלקס. לכאורה, אין בכך בעיה וזו התשובה שקיבלתי בזמנו מהפסיכיאטרית שלי. אולם בחיפוש אחר מחקרים בנושא עולה שיש קשר בין נטילת תרופות אנטי דכאוניות על-ידי גבר לבין פגיעה בד.נ.א שבזרע וכתוצאה מכך גם לעלייה בסיכון למומים מולדים. באילו מומים מדובר? האם כדאי לשקול הפסקת הריון? האם יש בדיקות שניתן לעשות כעת? הדבר מעורר בי חששות רבים במיוחד מפני מומים שלא ניתן לאתר בבדיקות, ובהחלט מדיר שינה מעיני. אשמח לעצתכם. להלן ציטוט מתוך המחקר שמצאתי: Results showed that the percent of participants with abnormal DNA fragmentation rose from less than 10 percent to 50 percent while taking the drug. DNA fragmentation, the authors note, is known to correlate with poorer fertility and pregnancy outcomes, even when techniques such as in vitro fertilization and intracytoplasmic sperm injection are applied. It has also been linked with an increased risk for birth defects. "It's fairly well known that SSRI antidepressants negatively impact erectile function and ejaculation. This study goes one step further, demonstrating that they can cause a major increase in genetic damage to sperm," Dr. Peter Schlegel, the study's senior author and chairman of the Department of Urology and professor of reproductive medicine at Weill Cornell Medical College, explained in a statement to the media. "Although this study doesn't look directly at fertility, we can infer that as many as half of men taking SSRIs have a reduced ability to conceive. These men should talk with their physician about their treatment options, including non-SSRI depression medications." The scientists could not identify the exact way the SSRI caused the DNA fragmentation, but the evidence strongly suggests the drug slows sperm as it moves through the male reproductive tract from the testis to the ejaculatory ducts. When this happens, the sluggish sperm grows old and its DNA becomes damaged. "This is a new concept for how drugs can affect fertility and sperm. In most cases, it was previously assumed that a drug damaged sperm production, so the concept that sperm transport could be affected is novel," Dr. Schlegel stated. The study contains some good news for men currently on Paxil and related drugs who may be concerned about their fertility. All the changes the researchers found appeared to be totally reversible. Specifically, normal levels of sexual function and DNA fragmentation both returned to normal one month after discontinuation of the drug.