בעיות פוריות ודלקת כרונית

יש מחקרים עם תוצאות סותרות בנתיים, למשל: J Assist Reprod Genet. 2008 Aug;25(8):383-8. Epub 2008 Sep 23. Links Low grade inflammation, as evidenced by basal high sensitivity CRP, is not correlated to outcome measures in IVF.Robinson S, Pemberton P, Laing I, Nardo LG. Department of Clinical Biochemistry, Manchester Royal Infirmary, Manchester, UK. PURPOSE: To assess the relationship between low-grade inflammation, measured as basal high sensitivity (hs)-CRP, AND IVF outcome. METHODS: We recruited a total of 220 women undergoing infertility work up prior to IVF. Patients were selected for a BMI < 30 kg/m(2) with an upper age limit of 40 years. Serum hs-CRP levels were measured on day 3 of a spontaneous menstrual cycle preceding ovarian stimulation. A sensitive two-site ELISA was used for analysis. Dose of gonadotrophins required, follicles days 8 AND 10, number of oocytes collected, number of oocytes fertilised AND pregnancy outcome were recorded. RESULTS: Median hs-CRP was 1.08 mg/L (0.43-3.00 mg/L). The hs-CRP was significantly related to BMI (r = 0.386, P < .001) but not to age AND smoking habit. There were no significant relationships between basal hs-CRP AND any of the measured IVF outcomes. CONCLUSIONS: These findings demonstrate that serum hs-CRP concentration is not a predictive marker of cycle OR pregnancy outcome in women undergoing IVF treatment. J Reprod Immunol. 2007 Oct;75(2):141-4. Epub 2007 Apr 27. Links Higher C-reactive protein levels during IVF stimulation are associated with ART failure.Levin I, Gamzu R, Mashiach R, Lessing JB, Amit A, Almog B. Department of Gynecology, Lis Maternity Hospital, Sourasky Medical Center, Tel-Aviv, Israel. [email protected] BACKGROUND: C-reactive protein (CRP) is believed to be a sensitive marker of endothelial activation AND inflammation. The association between an inflammatory state AND CRP has prompted research on changes in CRP levels in assisted reproductive technique (ART) cycles. IVF success AND CRP levels were not correlated previously. The aim of this prospective study was to assess CRP levels during IVF stimulation AND correlate them with IVF success. MATERIALS AND METHODS: Twenty-eight Women were stimulated using the 'Flare-up' protocol with down-regulation of Triprorelin. CRP levels were measured on cycle days 3, 8, ovum pick-up day AND 12 days following embryo-transfer (betahCG testing day). Main outcome measures: CRP levels in women who conceived after IVF protocol (n=8) were compared to CRP levels in women who failed to conceive (n=20). RESULTS: The mean age for both groups was similar. CRP levels were significantly different on day 3 (p<0.05), but not on day 8, of the cycle. Average CRP levels on ovum pick-up AND on betahCG test days were similar, as was the number of oocytes collected OR embryos replaced. Patients who failed to conceive had significantly higher levels of CRP on day 3 of the cycle, before commencement of gonadotrophin administration, AND the higher levels continued throughout treatment, although not reaching statistical significance. CONCLUSIONS: An inflammatory state, indicated by high CRP levels during stimulation, may serve as a prognostic indicator of IVF success.