למתענינים קצת חדשות בנושא הגנטי רצ"ב קישור

Subject: Gene discoveries provide ideas for better psoriasis treatments National Psoriasis Foundation CURE E-NEWS | JANUARY 2013 Having trouble? View on mobile | View as web page National Psoriasis Foundation logo In this edition: Scientists identify new genetic clues to psoriasis » NPF-backed study finds genetic link among pustular forms of psoriasis » This month's news » Scientists identify new genetic clues to psoriasis Dr. J.T. Elder presents at the National Psoriasis Foundation's Research Symposium In an international collaboration, scientists identified 15 new areas in our DNA, known as loci, which are associated with the development of psoriasis. Using a new research tool called an Immunochip, the group, including National Psoriasis Foundation-funded scientists Dr. James Elder of the University of Michigan and geneticist Anne Bowcock of Washington University in St. Louis, reanalyzed samples from previous genetic studies to identify variations in the genes that may increase psoriasis susceptibility. This new technology allows researchers to provide a more detailed map of the genes than previously was possible, making it possible to understand why some people are more likely to develop psoriasis than others, and to suggest targets for new and better treatments. The research, published in Nature Genetics, expanded on several genome-wide association studies—large studies that compare DNA from people with a disease and those without a disease to see if genetic variations are associated with the disease—by using DNA collected from the National Psoriasis Victor Henschel BioBank and other sources. The discovery increased the total number of genes believed to be involved in psoriasis to 36. While significant, these genes account for only 22 percent of people's psoriasis risk, so much more research is needed to find all the genes involved in psoriatic diseases. NPF-backed study finds genetic link among pustular forms of psoriasis New research reveals genetic similarities between generalized pustular psoriasis and the two other forms of pustular psoriasis known as palmoplantar pustular psoriasis—which appears on the palms of the hands and soles of the feet—and acropustulosis, a rare and severe variation of palmoplantar pustular psoriasis that causes lesions on the fingertips and sometimes the ends of the toes. The study, led by researcher Francesca Capon of King's College in London and backed by a 2012 National Psoriasis Foundation Discovery Grant, found that a gene called IL36RN might also be involved in these other forms of pustular psoriasis. Scientists have previously linked generalized pustular psoriasis, also known as von Zumbush pustular psoriasis, to mutations in the IL36RN gene. Data reveals that while the three types of pustular psoriasis manifest with different symptoms and are diagnosed and treated differently, they are genetically similar. This month's news: Skin solutions: Caring for psoriasis in the winter Wed., Jan. 16, 4 p.m. PST Learn how to reduce itching, flaking and redness in the winter months with this free webcast. Register today » Sacramento Psoriasis Talk Sat., Jan. 19, 9 a.m., Sacramento, CA Free presentation on living with psoriasis and psoriatic arthritis. Includes Q&A session with a leading dermatologist. Email [email protected] for more information. Northern California Division Meeting Tues., Jan. 22, 6:30 p.m., San Mateo, CA

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