אוסטאופורוזיס אצל ניצולי שואה

שמעתי על מחקרים שנעשו על ניצולי שואה אשר סבלו מרעב תהומי,ונמצא אצלם אוסטאופורוזיס, המוכיחים שסיבה להופעתו הייתה מצוקה ורעב קשה בגיל ילדות .העם הדבר ידוע לך.אבקשך חומר קריאה.כל מאמר טוב אבל עדיף בעברית.

שלום מיכאל ! מלשכת דובר הטכניון - http://pard.technion.ac.il/press/PressrelH.asp# יש שם פרטים על כנס "הרפואה והשואה" - 27/4/03 שבו הוצג מחקר בנושא: אוסטיאופורוזיס שכיחה יותר בקרב ניצולי שואה. תנסה להתקשר ללשכת דובר הטכניון ולהיעזר בהם. בהצלחה, חיפאית

שלום מיכאל ותודה לחיפאית, להלן תקציר של עבודת מחקר נוספת שהוצגה בכנס של ASBMR. המחקר בוצע בהדסה ירושלים. Long-Term Effects of Poor Environmental Conditions During Early Life: Increased Prevalence of Hip Fractures among Holocaust Survivors Presentation Time: Tuesday, 11:00 a.m. - 11:15 a.m. A. J. Foldes1, J. Brodsky*2, N. Bentur*2. 1Osteoporosis Center, Hadassah University Hospital, Jerusalem, Israel, 2JDC-Brookdale Institute of Gerontology, Jerusalem, Israel. Presentation Number: 1205 It has been suggested that senile osteoporosis is largely determined by peak bone mass which, in turn, is affected by a host of environmental factors. Comparing holocaust survivors to individuals of the same origin, who had not experienced the holocaust, provided us with a unique opportunity to test the relationship between detrimental conditions during early life and the prevalence of hip fractures (Fx) later in life. Data were derived from a population survey that was conducted during 1997-8 on a sample of 2,669 Ashkenazi Jews (1,350 females, 1,319 males), 60 years of age or more (median age = 74), born in Europe before World War II. The prevalence of self-reported hip Fx (based on any previous diagnosis by a physician of a Fx at the pelvic bone or the femora) was recorded. Based on their personal history during World War II, the study participants were stratified into three groups: (1) Survivors of Nazi concentration or labor camps; (2) “Other” survivors, who lived under Nazi occupation, but did not experience camps; (3) Control group, consisting of those who did not live under Nazi occupation during WW II. Prevalence of hip Fx (%) Odds ratio (camp survivors vs. controls) Total sample (n=2,669) Camp survivors (n=452) Other survivors (n=929) Controls (n=1,288) Total sample 4.8 9.0 4.6 3.3 2.9 Females 5.7 11.4 5.5 3.9 3.0 Males 3.6 6.8 3.1 2.4 2.3 Age75 8.1 7.9 9.5 7.3 NS The following conclusions can be drawn: (1) An almost threefold higher prevalence of hip Fx was observed among survivors of Nazi camps (9.0%), as compared to controls (3.3%), with intermediate values for “other” survivors. The extent of this finding may even be underestimated, given the “survival of the fits” phenomenon. (2) The camp effect was limited to the younger cohort, which consisted of individuals who were 16-17 year-old or younger at the onset of WWII. This observation is also manifested by the unexpected finding, that among the camp survivors, hip Fx prevalence in the younger cohort exceeded that observed in the older cohort! (3) In the older cohort, that included individuals who were past the age of 16-17 at the onset of WW II, no camp effect was observed. (4) In the younger cohort, the prevalence of hip Fx in males (3.0%) approached that of females (2.7%), while in the older cohort, the expected higher prevalence of hip Fx in females (10.5%) compared to males (4.8%) was maintained. The findings of this study support the notion that living under detrimental conditions during early life is associated with a higher risk of hip Fx later in life בברכה ד"ר צופיה איש-שלום