המנעות מדוש וגינלי חשובה למניעת המשך בעיות צואר הר

דיון מתוך פורום  אונקולוגיה גינקולוגית

17/02/2011 | 17:43 | מאת: ד"ר אילן אטלס

במאמר שבדק את הדוש הוגינלי לנשים נשאיות של HPV הדוש נמצא כלא בריא: Post-coital vaginal douching is risky for non-regression of low-grade squamous intraepithelial lesion of the cervix☆,☆☆ Tang-Yuan Chu a,b,⁎, Chao Agnes Hsiung c, Chi-An Chen d, Hung-Hsueh Chou e, Chih-Ming Ho f, Tsai-Yen Chien f, Hui-Ju Chang g, Cheng-Yang Chou h, Jui-Der Liou e, Yuen-Yee Kan i, Chang-Yao Hsieh d,⁎ a Department of Obstetrics and Gynecology, Buddhist Tzuchi General Hospital, Tzuchi University, Hualien, Taiwan b Institute of Medical Sciences, Tzuchi University, Hualien, Taiwan c Division of Biostatistics and Bioinformatics, National Health Research Institutes, Taipei, Taiwan d Department of Obstetrics and Gynecology, National Taiwan University Medical College, Taipei, Taiwan e Department of Obstetrics and Gynecology, Chang-Gung Memorial Hospital, Taipei, Taiwan f Department of Obstetrics and Gynecology, Cathay General Hospital, Taipei, Taiwan g Department of Obstetrics and Gynecology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan h Department of Obstetrics and Gynecology, National Cheng-Kung University Medical College, Tainan, Taiwan i Department of Obstetrics and Gynecology, Yuan's General Hospital, Kaohsiung, Taiwan a r t i c l e i n f o a b s t r a c t Article history: Received 2 September 2010 Available online 8 December 2010 Keywords: Human papillomavirus Vaginal douche Low-grade squamous intraepithelial lesion Background. Vaginal douching is a common practice worldwide. Its effect on the natural history of the early lesion of human papillomavirus (HPV) infection, low-grade squamous intraepithelial lesion (LSIL), is unknown. Methods. In a prospective nation-wide cohort (n=1332), epidemiological variables including habit of vaginal douching after intercourse and outcomes of LSIL were studied. Colposcopy-confirmed LSIL women (n=295) were followed every 3 months. Parameters of HPV infection, sexual behavior, personal hygiene and environmental exposures were compared with the follow-up outcomes. Results. There was a 15% chance of HSIL co-existing with the LSIL cytology result. Eight percent of colposcopyconfirmed LSIL were found with HSIL in 1 year. With a follow-up of up to 36 months, 83% LSIL regressed, 11% progressed and 6% persisted. The mean time (95% CIs) to regression and progression were 5.2 (4.7–5.8) and 8.0 (5.8–10.3)months, respectively. Risk factors of the non-regression of LSIL included HPV prevalence on enrollment, habit of vaginal douching after intercourse with a hygiene product and non-regular Pap screening,with odd ratio of 4.4 (1.9–10.3), 3.14 (1.04–9.49) and 2.12 (1.24–3.62), respectively. HPV prevalence and vaginal douching also conferred a slower regression of LSIL (8.0 vs. 4.1 months, Pb.001 and 8.0 vs. 5.6 months, P=0.02, respectively). Conclusion. The study disclosed a transient but warning nature of cytological LSIL. Practicing of vaginal douching after intercourse, especially with hygiene products, is associated with non-regression of LSIL. © 2010 Published by Elsevier

19/02/2011 | 12:14 | מאת: טלי

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