האם מותר לקחת ריטלין בשבועות הראשונים להריון ??
דיון מתוך פורום פריון האישה והפריה חוץ גופית
אין ידע מספיק על בטיחות התרופה בהריון ולכן מותר לקחת אותה רק במידה והרופא סבור שהתועלת שבנטילתה עולה על הסיכון התיאורטי לעובר. ראי גם: Pregnancy Category C In studies conducted in rats AND rabbits, methylphenidate was administered orally at doses of up to 75 AND 200 mg/kg/day, respectively, during the period of organogenesis. Teratogenic effects (increased incidence of fetal spina bifida) were observed in rabbits at the highest dose, which is approximately 40 times the maximum recommended human dose (MRHD) on a mg/m2 basis. The no effect level for embryo-fetal development in rabbits was 60 mg/kg/day (11 times the MRHD on a mg/m2 basis). There was no evidence of specific teratogenic activity in rats, although increased incidences of fetal skeletal variations were seen at the highest dose level (7 times the MRHD on a mg/m2 basis), which was also maternally toxic. The no effect level for embryo-fetal development in rats was 25 mg/kg/day (2 times the MRHD on a mg/m2 basis). When methylphenidate was administered to rats throughout pregnancy AND lactation at doses of up to 45 mg/kg/day, offspring body weight gain was decreased at the highest dose (4 times the MRHD on a mg/m2 basis), but no other effects on postnatal development were observed. The no effect level for pre- AND postnatal development in rats was 15 mg/kg/day (equal to the MRHD on a mg/m2 basis). Adequate AND well-controlled studies in pregnant women have not been conducted. Ritalin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
