Someting

Can you help me out please?! I found this on our cancer forum but for some reasons I can not contact the lady who posted it. All I know that it is a product made in Israel. Can anyone direct me to the company or to an Israeli on line Pharmacy?! Topic: For all of us (1 of 1), Read 1055 times Conf: Breast Cancer From: Deby Nolan Date: Wednesday, December 17, 2003 05:39 AM Point4 Life ™ (Abstract from clinical trials protocol) Introduction: Fatigue/asthenia is the most common symptom described by patients with cancer with a prevalence ranging from 60% to more than 90%, and many persist after cure of cancer. Perhaps no other symptom is more classically associated with cancer than fatigue. Furthermore fatigue is often cited as the most disruptive symptom of a patients daily routine (5). The symptom accompanies surgery, chemotherapy, radiation therapy, and biologic response modifier therapy. Chemotherapy- and radiation-therapy-related fatigue may be associated with anemia or with an accumulation of cell destruction end products.[1,2] In the case of radiation therapy, fatigue may be caused by increased energy requirements to repair damaged epithelial tissue.[3 Adrenal insufficiency, in critically ill patients were the corticotropic axis is greatly activated causing cortisol concentration, should be considered as a major contributing factor (7). Although the exact mechanism of fatigue in patients with cancer is often not known its causes are diverse. A high frequency of fatigue is reported after different treatments, including surgery, chemotherapy, and bone marrow transplantation. Chemotherapy has been reported to cause fatigue in 75% to 100% of cases, with the symptoms persisting months to years after the treatment is completed. Although radiation therapy is a localized treatment, the incidence of fatigue with its use runs high, especially with abdominal radiation. Fatigue increases during radiation therapy and can endure for many months after the treatment is completed. In addition numerous factors related to the moods, beliefs, attitudes, and reactions to stressors of people with cancer are thought to contribute to the development of chronic fatigue.(4) Adrenal insufficiency in critically ill patients, were the corticotropic axis is greatly activated causing cortisol concentration that correlates with illness-severity and are highest in individuals with highest mortality (7).is also a major Fatigue (lack of energy, stamina, gastric pain, weight loss, nausea, vomiting, dizziness….) inducing factor that should be addressed when coming to treat it. (7) Because the etiology of cancer related fatigue is generally multifactoral the pharmaceutical management should, whenever possible, be directed toward etiology.(5) Point4Life™ is designed to answer to such, major, etiological factors namely: The regulation of "non-specific-stress" harmful effects on the body's homeostatic mechanism. Rational: Point4Life™ development is based on the well researched and documented thesis that non-specific-stress is playing a dominant role in cancer related fatigue and that Point4Life™'s ingredients, may exaggerate an already existing biphasic response to stress via inhibition of enzymes which limit the binding of stress hormones to their receptors (8) and by thus protect body from their harmful effects. Mechanism of action: (abstract) The probable biphasic effect results from increased occupancy of positive and negative feedback stress hormone receptors by their natural ligands due to inhibition of specific enzymes which function to limit receptor occupancy. Specially is suggested that PG (Panax G.) inhibits 11-beta hydroxysteroid dehydrogenase one and ES (Eleutherococcus S) inhibits catechol-O-methyl transferase, both of which reside in close proximity to stress hormone receptors and catalyze the degradation of stress hormones into inactive compounds. In addition it is suggested that the increased energy said to result from PG and may be a consequence of their increasing the occupancy of stress hormone receptors which function to redistribute the body's energy reserves from regeneration to activity. (8) Indications: Point4Life™ is an adjuvant / complementary therapy to surgical, chemo and radiation therapies, as well as following marrow transplantation. Point4Life™is expected to increase body's nonspecific resistance to physical and mental stressors, protect body from harmful effects at cellular level and by thus to minimize fatigue symptoms generally associated with cancer and critical illnesses i.e. lack of energy, stamina, gastric pain, weight loss, nausea, vomiting, dizziness… "Post-treatment" - Due to its "homeostasis regulatory" (biphasic response to stress (8) attributes, Point4Life™ is expected to play a significant role in the convalescence of critically ill patients and offer "protection" against reoccurrence or development of cancer (6). References: 1. Glaspy J, Bukowski R, Steinberg D, et al.: Impact of therapy with epoetin alfa on clinical outcomes in patients with nonmyeloid malignancies during cancer chemotherapy in community oncology practice. Procrit Study Group. J Clin Oncol 15 (3): 1218-34, 1997. 2. Cella D, Mo F, Peterman A: Anemia, fatigue, and quality of life in people with cancer and HIV infection. [Abstract] Blood 88 (10 Suppl 1): A-571, 146a, 1996. 3. Haylock PJ, Hart LK: Fatigue in patients receiving localized radiation. Cancer Nurs 2(6): 461-467, 1979. 4. Reich SG: The tired patient: psychological versus organic causes. Hosp Med 22 (7): 142-154, 1986. 5. Roger Waltzman: Chalenges of Treating Cancer-Related Fatigue. Oncology – Special Edition (4): 35-39, 2001 6. Lillberg K, Vercasalo PK, et al: Stressful life events and risk of breast cancer in 10,808 women: a cohort study. Am J Epidemol 2003 Mar 1:157(5):415-23 7. Wiebke Arlt, Bruno Allolio: Adrenal insufficiency. The Lancet 2003;361:1881-93 8. Gafney BT, Hugel HM, Rich PA. Panax G. and Eleutherococcus senticosus may exaggerate an already existing biphasic response to stress via inhibition of enzymes which limit the binding of stress hormones to their receptors. Medical Hypotheses 2001; 56(5): 567-572

: Someting מחבר: Petra - Viena תאריך: 25-12-2003 15:46 Can you help me out please?! I found this on our cancer forum but for some reasons I can not contact the lady who posted it. All I know that it is a product made in Israel. Can anyone direct me to the company or to an Israeli on line Pharmacy?! Topic: For all of us (1 of 1), Read 1055 times Conf: Breast Cancer From: Deby Nolan Date: Wednesday, December 17, 2003 05:39 AM Point4 Life ™ (Abstract from clinical trials protocol) Introduction: Fatigue/asthenia is the most common symptom described by patients with cancer with a prevalence ranging from 60% to more than 90%, and many persist after cure of cancer. Perhaps no other symptom is more classically associated with cancer than fatigue. Furthermore fatigue is often cited as the most disruptive symptom of a patients daily routine (5). The symptom accompanies surgery, chemotherapy, radiation therapy, and biologic response modifier therapy. Chemotherapy- and radiation-therapy-related fatigue may be associated with anemia or with an accumulation of cell destruction end products.[1,2] In the case of radiation therapy, fatigue may be caused by increased energy requirements to repair damaged epithelial tissue.[3 Adrenal insufficiency, in critically ill patients were the corticotropic axis is greatly activated causing cortisol concentration, should be considered as a major contributing factor (7). Although the exact mechanism of fatigue in patients with cancer is often not known its causes are diverse. A high frequency of fatigue is reported after different treatments, including surgery, chemotherapy, and bone marrow transplantation. Chemotherapy has been reported to cause fatigue in 75% to 100% of cases, with the symptoms persisting months to years after the treatment is completed. Although radiation therapy is a localized treatment, the incidence of fatigue with its use runs high, especially with abdominal radiation. Fatigue increases during radiation therapy and can endure for many months after the treatment is completed. In addition numerous factors related to the moods, beliefs, attitudes, and reactions to stressors of people with cancer are thought to contribute to the development of chronic fatigue.(4) Adrenal insufficiency in critically ill patients, were the corticotropic axis is greatly activated causing cortisol concentration that correlates with illness-severity and are highest in individuals with highest mortality (7).is also a major Fatigue (lack of energy, stamina, gastric pain, weight loss, nausea, vomiting, dizziness….) inducing factor that should be addressed when coming to treat it. (7) Because the etiology of cancer related fatigue is generally multifactoral the pharmaceutical management should, whenever possible, be directed toward etiology.(5) Point4Life™ is designed to answer to such, major, etiological factors namely: The regulation of "non-specific-stress" harmful effects on the body's homeostatic mechanism. Rational: Point4Life™ development is based on the well researched and documented thesis that non-specific-stress is playing a dominant role in cancer related fatigue and that Point4Life™'s ingredients, may exaggerate an already existing biphasic response to stress via inhibition of enzymes which limit the binding of stress hormones to their receptors (8) and by thus protect body from their harmful effects. Mechanism of action: (abstract) The probable biphasic effect results from increased occupancy of positive and negative feedback stress hormone receptors by their natural ligands due to inhibition of specific enzymes which function to limit receptor occupancy. Specially is suggested that PG (Panax G.) inhibits 11-beta hydroxysteroid dehydrogenase one and ES (Eleutherococcus S) inhibits catechol-O-methyl transferase, both of which reside in close proximity to stress hormone receptors and catalyze the degradation of stress hormones into inactive compounds. In addition it is suggested that the increased energy said to result from PG and may be a consequence of their increasing the occupancy of stress hormone receptors which function to redistribute the body's energy reserves from regeneration to activity. (8) Indications: Point4Life™ is an adjuvant / complementary therapy to surgical, chemo and radiation therapies, as well as following marrow transplantation. Point4Life™is expected to increase body's nonspecific resistance to physical and mental stressors, protect body from harmful effects at cellular level and by thus to minimize fatigue symptoms generally associated with cancer and critical illnesses i.e. lack of energy, stamina, gastric pain, weight loss, nausea, vomiting, dizziness… "Post-treatment" - Due to its "homeostasis regulatory" (biphasic response to stress (8) attributes, Point4Life™ is expected to play a significant role in the convalescence of critically ill patients and offer "protection" against reoccurrence or development of cancer (6). References: 1. Glaspy J, Bukowski R, Steinberg D, et al.: Impact of therapy with epoetin alfa on clinical outcomes in patients with nonmyeloid malignancies during cancer chemotherapy in community oncology practice. Procrit Study Group. J Clin Oncol 15 (3): 1218-34, 1997. 2. Cella D, Mo F, Peterman A: Anemia, fatigue, and quality of life in people with cancer and HIV infection. [Abstract] Blood 88 (10 Suppl 1): A-571, 146a, 1996. 3. Haylock PJ, Hart LK: Fatigue in patients receiving localized radiation. Cancer Nurs 2(6): 461-467, 1979. 4. Reich SG: The tired patient: psychological versus organic causes. Hosp Med 22 (7): 142-154, 1986. 5. Roger Waltzman: Chalenges of Treating Cancer-Related Fatigue. Oncology – Special Edition (4): 35-39, 2001 6. Lillberg K, Vercasalo PK, et al: Stressful life events and risk of breast cancer in 10,808 women: a cohort study. Am J Epidemol 2003 Mar 1:157(5):415-23 7. Wiebke Arlt, Bruno Allolio: Adrenal insufficiency. The Lancet 2003;361:1881-93 8. Gafney BT, Hugel HM, Rich PA. Panax G. and Eleutherococcus senticosus may exaggerate an already existing biphasic response to stress via inhibition of enzymes which limit the binding of stress hormones to their receptors. Medical Hypotheses 2001; 56(5): 567-572

Can you help me out please?! I found this on our cancer forum but for some reasons I can not contact the lady who posted it. All I know that it is a product made in Israel. Can anyone direct me to the company or to an Israeli on line Pharmacy?! Point4 Life ™ (Abstract from clinical trials protocol) Introduction: Fatigue/asthenia is the most common symptom described by patients with cancer with a prevalence ranging from 60% to more than 90%, and many persist after cure of cancer. Perhaps no other symptom is more classically associated with cancer than fatigue. Furthermore fatigue is often cited as the most disruptive symptom of a patients daily routine (5). The symptom accompanies surgery, chemotherapy, radiation therapy, and biologic response modifier therapy. Chemotherapy- and radiation-therapy-related fatigue may be associated with anemia or with an accumulation of cell destruction end products.[1,2] In the case of radiation therapy, fatigue may be caused by increased energy requirements to repair damaged epithelial tissue.[3 Adrenal insufficiency, in critically ill patients were the corticotropic axis is greatly activated causing cortisol concentration, should be considered as a major contributing factor (7). Although the exact mechanism of fatigue in patients with cancer is often not known its causes are diverse. A high frequency of fatigue is reported after different treatments, including surgery, chemotherapy, and bone marrow transplantation. Chemotherapy has been reported to cause fatigue in 75% to 100% of cases, with the symptoms persisting months to years after the treatment is completed. Although radiation therapy is a localized treatment, the incidence of fatigue with its use runs high, especially with abdominal radiation. Fatigue increases during radiation therapy and can endure for many months after the treatment is completed. In addition numerous factors related to the moods, beliefs, attitudes, and reactions to stressors of people with cancer are thought to contribute to the development of chronic fatigue.(4) Adrenal insufficiency in critically ill patients, were the corticotropic axis is greatly activated causing cortisol concentration that correlates with illness-severity and are highest in individuals with highest mortality (7).is also a major Fatigue (lack of energy, stamina, gastric pain, weight loss, nausea, vomiting, dizziness….) inducing factor that should be addressed when coming to treat it. (7) Because the etiology of cancer related fatigue is generally multifactoral the pharmaceutical management should, whenever possible, be directed toward etiology.(5) Point4Life™ is designed to answer to such, major, etiological factors namely: The regulation of "non-specific-stress" harmful effects on the body's homeostatic mechanism. Rational: Point4Life™ development is based on the well researched and documented thesis that non-specific-stress is playing a dominant role in cancer related fatigue and that Point4Life™'s ingredients, may exaggerate an already existing biphasic response to stress via inhibition of enzymes which limit the binding of stress hormones to their receptors (8) and by thus protect body from their harmful effects. Mechanism of action: (abstract) The probable biphasic effect results from increased occupancy of positive and negative feedback stress hormone receptors by their natural ligands due to inhibition of specific enzymes which function to limit receptor occupancy. Specially is suggested that PG (Panax G.) inhibits 11-beta hydroxysteroid dehydrogenase one and ES (Eleutherococcus S) inhibits catechol-O-methyl transferase, both of which reside in close proximity to stress hormone receptors and catalyze the degradation of stress hormones into inactive compounds. In addition it is suggested that the increased energy said to result from PG and may be a consequence of their increasing the occupancy of stress hormone receptors which function to redistribute the body's energy reserves from regeneration to activity. (8) Indications: Point4Life™ is an adjuvant / complementary therapy to surgical, chemo and radiation therapies, as well as following marrow transplantation. Point4Life™is expected to increase body's nonspecific resistance to physical and mental stressors, protect body from harmful effects at cellular level and by thus to minimize fatigue symptoms generally associated with cancer and critical illnesses i.e. lack of energy, stamina, gastric pain, weight loss, nausea, vomiting, dizziness… "Post-treatment" - Due to its "homeostasis regulatory" (biphasic response to stress (8) attributes, Point4Life™ is expected to play a significant role in the convalescence of critically ill patients and offer "protection" against reoccurrence or development of cancer (6). References: 1. Glaspy J, Bukowski R, Steinberg D, et al.: Impact of therapy with epoetin alfa on clinical outcomes in patients with nonmyeloid malignancies during cancer chemotherapy in community oncology practice. Procrit Study Group. J Clin Oncol 15 (3): 1218-34, 1997. 2. Cella D, Mo F, Peterman A: Anemia, fatigue, and quality of life in people with cancer and HIV infection. [Abstract] Blood 88 (10 Suppl 1): A-571, 146a, 1996. 3. Haylock PJ, Hart LK: Fatigue in patients receiving localized radiation. Cancer Nurs 2(6): 461-467, 1979. 4. Reich SG: The tired patient: psychological versus organic causes. Hosp Med 22 (7): 142-154, 1986. 5. Roger Waltzman: Chalenges of Treating Cancer-Related Fatigue. Oncology – Special Edition (4): 35-39, 2001 6. Lillberg K, Vercasalo PK, et al: Stressful life events and risk of breast cancer in 10,808 women: a cohort study. Am J Epidemol 2003 Mar 1:157(5):415-23 7. Wiebke Arlt, Bruno Allolio: Adrenal insufficiency. The Lancet 2003;361:1881-93 8. Gafney BT, Hugel HM, Rich PA. Panax G. and Eleutherococcus senticosus may exaggerate an already existing biphasic response to stress via inhibition of enzymes which limit the binding of stress hormones to their receptors. Medical Hypotheses 2001; 56(5): 567-572

Hi Petra, There is a woman who promotes this product and posted several messages on our forum. Try her at this address: [email protected].