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# תה ירוק עשיר באנטיאוקסידנטים וחומרים נוספים בעלי פעילות אנטי סרטנית. # הפעילות האנטיסרטנית הודגמה בעיקר בתרביות תאים ובעכברים נושאי גידולים. # מספר מחקרים, בעיקר מיפן וממזרח אסיה, הראו כי שתיית תה ירוק עשוייה למנוע (למנוע, לא לרפא) הופעת כידולים מסויימים בבני אדם. במחקרים אחרים לא נמצאה פעילות מניעתית כזו. # במחקרים קליניים מבוקרים שנערכו עד כה, צריכת תה ירוק ע"י חולי סרטן לא משנה את מהלך המחלה. # לא כל מה שפעיל בתרביות תאים ובעכברים פעיל בבני אדם. ********************************************************************** How useful are unconventional cancer treatments? Eur J Cancer. 1999 Oct;35(11):1608-13. Unconventional cancer treatments are used frequently. Therefore, oncologists need to know about them. This article gives an overview of current knowledge on the most prevalent complementary OR alternative cancer therapies. A distinction is made between alleged cures, preventive AND adjunctive measures. Shark cartilage, mistletoe, thymus therapy, essiac, hydrazine sulphate, 714-X, dietary regimens, green tea AND Panax ginseng are all covered specifically. None of these treatments offer reasonable hope for a cure. Some strategies are promising in terms of cancer prevention. The true potential of unconventional therapies might lie in adjunctive AND palliative care. It is concluded that good evidence in this area is scarce. Vis-a-vis the high prevalence of unconventional cancer treatments, rigorous investigations are mandatory, not least for increasing the safety of future patients. ------------------------------------------------------- Green Tea AMERICAN CANCER SOCIETY Other common name(s): green tea extract, Chinese tea Scientific/medical name(s): Camellia sinesis Description Green tea is a drink made from the steamed AND dried leaves of the Camellia sinesis plant, a shrub native to Asia. Black tea is also made from this plant, but unlike green tea, it is made from leaves that have been fermented. (This may reduce the levels of some compounds, such as antioxidants, in black tea.) Overview Some researchers believe green tea may have a protective effect against certain cancers because it contains antioxidants. However, results from human studies have been mixed. More research is needed to determine its role in cancer prevention. How is it promoted for use? Green tea is widely consumed in Japan, China, AND other Asian nations AND is becoming more popular in Western nations. Some reports indicate green tea may have the ability to help prevent cancers of the skin, esophagus, stomach, colon, pancreas, lung, bladder, prostate, AND breast. Green tea contains chemicals known as polyphenols, which have antioxidant properties. Catechins are the major group of polyphenols in green tea. The most important catechin seems to be epigallocatechin-3-gallate (EGCG). EGCG may cause cancer cells to die like normal cells do. It may also work by stopping new blood vessels from forming, a process called angiogenesis, thereby cutting off the supply of blood to cancer cells. Herbalists use green tea AND extracts of its leaves for stomach problems, vomiting, AND diarrhea, AND to reduce tooth decay, blood pressure, cholesterol levels, AND blockages of the blood vessels in the heart that can lead to heart attacks. Green tea is also promoted as an herb that can prevent certain bacterial infections. In recent years, some researchers have suggested that black tea may also be effective in cancer prevention. These claims are currently being studied. What does it involve? The amount of green tea consumed varies widely, AND it is not clear how much might be needed for beneficial effects. Three cups a day OR more is the amount typically taken in Asian countries. Green tea is usually brewed using 1 to 2 teaspoons of the dried tea in a cup of boiling water OR is steeped for 3 to 15 minutes. Green tea extracts are also available in capsule form. Three capsules of green tea extract a day are often recommended by proponents, but this dosage AND its effects remain uncertain. There is wide variation in the contents of these extracts. Because they are sold as dietary supplements in the Unites States (as opposed to drugs), companies that market them do not have to prove they are effective, OR even safe, as long as they don?’t claim they can prevent, treat, OR cure a specific disease. Unlike drugs, dietary supplements are not highly regulated in terms of ensuring the contents match what is described on the product label. What is the history behind it? The Chinese have been drinking green tea to promote good health for at least 3,000 years. In recent years, scientists have begun to study its health effects more closely in lab animals AND in observational human studies. What is the evidence? ----------------------------- Many lab studies in cell cultures AND animals have shown green tea has activity against cancer cells. It is tempting to assume that it may therefore help prevent some cancers, but studies in humans have been mixed. Most human studies have been population-based studies done in East Asia, in which researchers compared tea drinkers with non-tea drinkers while trying to account for other lifestyle differences. These types of studies are complex, AND it is often hard to draw firm conclusions from them. Large population-based studies in East Asia generally have not found that green tea drinkers have a lower risk of breast, stomach, OR colon cancers than non-tea drinkers. One study found that Asian-American women who drink green tea regularly have a lower risk of breast cancer than those who do not. A Chinese study found that green tea drinking was associated with fewer cancers of the esophagus for people who did not smoke. Other studies of green tea?’s ability to prevent OR treat lung, prostate, bladder, OR other cancers have yielded similarly mixed results. While the results of lab studies have been promising, at this time there is no conclusive evidence that green tea can help prevent OR treat any specific type of cancer in humans. Controlled, randomized clinical trials are needed to determine its effectiveness. Several studies are currently under way. Are there any possible problems OR complications? Green tea is generally considered safe. Asians have consumed this tea for thousands of years with few dangerous side effects. However, some people may develop allergic reactions AND should stop drinking it. Drinking large amounts of tea may cause nutritional AND other problems because of the caffeine content AND the strong binding activities of the polyphenols. Possible effects from too much caffeine are the major concern with green tea. Too much caffeine can lead to nausea, trouble sleeping, AND frequent urination. Because caffeine acts as a stimulant, people with irregular heartbeats OR who have anxiety attacks should be cautious in its use. Women who are pregnant OR breast-feeding should not drink green tea in large amounts. Caffeine can cross the placenta AND be passed along in breast milk. Relying on this type of treatment alone, AND avoiding conventional medical care, may have serious health consequences.

: JAMA AND Archives Journals Date: September 13, 2006 Consumption Of Green Tea Associated With Reduced Mortality In Japanese Adults Adults in Japan who consumed higher amounts of green tea had a lower risk of death due to all causes AND due to cardiovascular disease, according to a study in the September 13 issue of JAMA. But there was no link between green tea consumption AND a reduced risk of death due to cancer. -------------------------------------------------------------------------------- Tea is the most consumed beverage in the world aside from water. Three billion kilograms of tea are produced each year worldwide, according to background information in the article. Because of the high rates of tea consumption in the global population, even small effects in humans could have large implications for public health. Among teas, green tea polyphenols have been extensively studied as cardiovascular disease (CVD) AND cancer chemopreventive agents. Although substantial evidence from in vitro AND animal studies indicates that green tea preparations may impede CVD AND carcinogenic processes, the possible protective role of green tea consumption against these diseases in humans remains unclear. Shinichi Kuriyama, M.D., Ph.D., of the Tohoku University School of Public Policy, Sendai, Japan, AND colleagues examined the association between green tea consumption AND mortality (death rate) due to all causes, CVD, AND cancer within a large population. The study, initiated in 1994, included 40,530 adults (age 40 to 79 years) in northeastern Japan, where green tea is widely consumed. Within this region, 80 percent of the population drinks green tea AND more than half of them consume 3 OR more cups AND day. The participants, who had no history of stroke, coronary heart disease, OR cancer at baseline, were followed for up to 11 years (1995-2005) for all-cause death AND for up to 7 years (1995-2001) for cause-specific death. Over 11 years of follow-up, 4,209 participants died, AND over 7 years of follow-up, 892 participants died of cardiovascular disease AND 1,134 participants died of cancer. The researchers found that green tea consumption was inversely associated with death due to all causes AND due to cardiovascular disease. Compared with participants who consumed less than 1 cup/d of green tea, those who consumed 5 OR more cups/d had a risk of all-cause mortality AND CVD mortality that was 16 percent lower (during 11 years of follow-up) AND 26 percent lower (during 7 years of follow-up), respectively. These inverse associations of all-cause AND CVD mortality were stronger among women, although the inverse association for green tea consumption was observed in both sexes. In women, compared with those who consumed less than 1 cup/d of green tea, those who consumed 5 OR more cups/d had a 31 percent lower risk of CVD death. The researchers found no significant association between green tea consumption AND death from cancer. There were weak OR neutral relationships between black tea OR oolong tea AND mortality. "Clinical trials are ultimately necessary to confirm the protective effect of green tea on mortality," the authors write.

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חייך אכלת אותה Jpn J Cancer Res. 1998 Mar;89(3):254-61. Links Influence of drinking green tea on breast cancer malignancy among Japanese patients.Nakachi K, Suemasu K, Suga K, Takeo T, Imai K, Higashi Y. Department of Epidemiology, Saitama Cancer Center Research Institute. Inhibitory effects of green tea on carcinogenesis have been investigated in numerous laboratory studies using (-)-epigallocatechin gallate (EGCG) OR crude green tea extract, AND there is also some epidemiologic evidence. Further, EGCG has been reported to inhibit the growth of cancer cells, lung metastasis in an animal model, AND urokinase activity. In this study, we first examined the association between consumption of green tea prior to clinical cancer onset AND various clinical parameters assessed at surgery among 472 patients with stage I, II, AND III breast cancer. We found that increased consumption of green tea was closely associated with decreased numbers of axillary lymph node metastases among premenopausal patients with stage I AND II breast cancer AND with increased expression of progesterone receptor (PgR) AND estrogen receptor (ER) among postmenopausal ones. Since these are potential prognostic factors, we then investigated the prognosis of breast cancer with special reference to consumption of green tea, in a follow-up study of these patients. We found that increased consumption of green tea was correlated with decreased recurrence of stage I AND II breast cancer (P < 0.05 for crude disease-free survival); the recurrence rate was 16.7 OR 24.3% among those consuming > OR = 5 cups OR < OR = 4 cups per day, respectively, in a seven-year follow-up of stage I AND II breast cancer, AND the relative risk of recurrence was 0.564 (95% confidence interval, 0.350-0.911) after adjustment for other lifestyle factors. However, no improvement in prognosis was observed in stage III breast cancer. Our results indicate that increased consumption of green tea prior to clinical cancer onset is significantly associated with improved prognosis of stage I AND II breast cancer, AND this association may be related to a modifying effect of green tea on the clinical characteristics of the cancer. PMID: 9600118 [PubMed - indexed for MEDLINE] זה מתייחס גם לדלקת פרקים, אסטמה, מניעת סרטן, פוריות, מניעת התקפי לב, כולסטרול גבוה, הגברת זיכרון, סיפטומי מנופאוזה, יכולת מנטלית, הגנה מפני קרינת השמש. אתה לא יכול לבטל עד כמה שתנסה את כל המידע הזה והמשמעות שלו עוד בקשר לסרטן: anonymous. Green tea AND leukoplakia. The Indian-US Head AND Neck Cancer Cooperative Group. Am J Surg. 1997;174(5):552-555 Ewertz, M. AND Gill, C. Dietary factors AND breast-cancer risk in Denmark. Int J Cancer 11-15-1990;46(5):779-784. Fujiki, H., Suganuma, M., Okabe, S., Sueoka, N., Komori, A., Sueoka, E., Kozu, T., Tada, Y., Suga, K., Imai, K., AND Nakachi, K. Cancer inhibition by green tea. Mutat.Res 6-18-1998;402(1-2):307-310 Gao, Y. T., McLaughlin, J. K., Blot, W. J., Ji, B. T., Dai, Q., AND Fraumeni, J. F., Jr. Reduced risk of esophageal cancer associated with green tea consumption. J Natl.Cancer Inst. 6-1-1994;86(11):855-858 Ahmad, N., Mohan, R. R., Husain, M. M., AND Mukhtar, H. Prostate cancer chemoprevention by green tea: in vitro AND in vivo inhibition of testosterone-mediated induction of ornithine decarboxylase. Cancer Res 5-1-1999;59(9):2115-2120. month tea intervention on oxidative DNA damage among heavy smokers: role of glutathione S-transferase genotypes. Cancer Epidemiol.Biomarkers Prev. 2004;13(2):242-249. Hsu, S., Lewis, J., Singh, B., Schoenlein, P., Osaki, T., Athar, M., Porter, A. G., AND Schuster, G. Green tea polyphenol targets the mitochondria in tumor cells inducing caspase 3-dependent apoptosis. Anticancer Res 2003;23(2B):1533-1539. Imai, K., Suga, K., AND Nakachi, K. Cancer-preventive effects of drinking green tea among a Japanese population. Prev.Med 1997;26(6):769-775. Lambert, J. D. AND Yang, C. S. Cancer chemopreventive activity AND bioavailability of tea AND tea polyphenols. Mutat.Res 2003;523-524:201-208 Lambert, J. D. AND Yang, C. S. Mechanisms of cancer prevention by tea constituents. J Nutr. 2003;133(10):3262S-3267S. Mei, Y., Wei, D., AND Liu, J. Reversal of cancer multidrug resistance by tea polyphenol in KB cells. J Chemother. 2003;15(3):260-265. Morre, D. J., Morre, D. M., Sun, H., Cooper, R., Chang, J., AND Janle, E. M. Tea catechin synergies in inhibition of cancer cell proliferation AND of a cancer specific cell surface oxidase (ECTO-NOX). Pharmacol.Toxicol. 2003;92(5):234-241. Fujiki, H., Suganuma, M., Okabe, S., Sueoka, N., Komori, A., Sueoka, E., Kozu, T., Tada, Y., Suga, K., Imai, K., AND Nakachi, K. Cancer inhibition by green tea. Mutat.Res 6-18-1998;402(1-2):307-310 Gao, Y. T., McLaughlin, J. K., Blot, W. J., Ji, B. T., Dai, Q., AND Fraumeni, J. F., Jr. Reduced risk of esophageal cancer associated with green tea consumption. J Natl.Cancer Inst. 6-1-1994;86(11):855-858. Afaq, F., Adhami, V. M., Ahmad, N., AND Mukhtar, H. Inhibition of ultraviolet B-mediated activation of nuclear factor kappaB in normal human epidermal keratinocytes by green tea Constituent (-)-epigallocatechin-3-gallate. Oncogene 2-20-2003;22(7):1035-1044