לא ברורה לי שאלה. האם מדובר ב-AED - דפיברילטור אוטומטי? ידני? לצורך מה? איפה ימוקם? יש פרמטרים חשובים במעפיינים של דפיברילטורים חוץ מעוצמה - וכדאי לקחת בחשבון את כולם.
T4 ו T3 לא מזריקים נותנים כדורים המכילים T4 מצאתי מאמר אחד בו יש קשר בין לווטרים לרמות נמוכות שלFT4 בחלק מהמטופלים . התיעץ עם אנדוקרינולוג מבוגרים. זה לא האתר המתאים Seizure . 2017 May;48:7-10. doi: 10.1016/j.seizure.2017.03.011. Epub 2017 Mar 19. Effects of antiepileptic drugs on thyroid hormone function in epilepsy patients Fu-Yuan Shih 1, Yao-Chung Chuang 2, Ming-Jung Chuang 1, Yan-Ting Lu 3, Wan-Chen Tsai 3, Ting-Ying Fu 4, Meng-Han Tsai 5 Affiliations expand PMID: 28364656 DOI: 10.1016/j.seizure.2017.03.011 Abstract Purpose: Patients with epilepsy are frequently required to take antiepileptic drugs (AEDs) for a long period of time. Many studies have shown that AEDs have a negative influence on endocrine function including the thyroid gland, however the risk factors for the development of low thyroid function in these patients are unclear. This study aimed to determine the potential risk factors of low thyroid function in patients with epilepsy. Method: This was a cross-sectional study including 298 patients with epilepsy. Patients with previous thyroid disease were excluded. Epidemiologic data, type of epilepsy, etiology, the age of seizure onset, duration of epilepsy, intractable epilepsy, and number and dosage of AEDs were recorded. Levels of free thyroxine (fT4) and thyroid stimulating hormone (TSH) were measured. Results: Fifty-two of the 298 (17.4%) patients had low fT4. Older age (P=0.004), female sex (P=0.014), longer duration of epilepsy (P=0.001), and intractable epilepsy (P=0.009) were significantly associated with low fT4. Regarding individual AEDs, carbamazepine (30.1%), topiramate (28.6%), and levetiracetam (24.3%) were significantly associated with the presence of low fT4. After stepwise logistic regression of all significant variables, female sex, older age, three or more AEDs, and carbamazepine were independent risk factors for low fT4. Conclusions: Female patients with epilepsy and an older age, AED polytherapy, and carbamazepine treatment had a higher risk of low fT4. Thyroid function in these patients should be monitored closely. Keywords: Antiepileptic drugs; Epilepsy; Risk factor; Thyroid function.
יתכן ולתרופות אלו השפעה על איכות התנועה של הזרע להלן מאמר בנושא Effects of antiepileptic drugs on sperm motility of normal controls and epileptic patients with long-term therapy. AuthorsChen SS, et al. Show all Journal Epilepsia. 1992 Jan-Feb;33(1):149-53. Affiliation Department of Neurology, Kaohsiung Medical College, Taiwan, R.O.C. Abstract The in vitro effects of four antiepileptic drugs (AEDs) on human sperm motility were studied with a transmembrane migration method. Sperm motility of epileptic patients receiving chronic AED therapy was also investigated. Sperm motility was measured immediately after semen had been mixed with AED and after a 2-h preincubation at 37 degrees C. Both in vitro and in vivo studies demonstrated that AEDs inhibited sperm motility. When the drug effect was evaluated after the semen-AED mixture had been preincubated for 2 h, sperm motility was inhibited to 50% of control at concentrations of 1.59, 4.23, and 5.00 mM for phenytoin, carbamazepine, and valproate, respectively. Both with and without preincubation, phenobarbital, even up to 12.92 mM, did not inhibit the motility to less than 50% of the control. In the in vivo study, poor sperm motility was noted in epileptic patients with long-term AED therapy despite serum levels within the therapeutic range. Shorter duration of activity of spermatozoa was also observed in these patients. Interference with sperm membrane function by AEDs may be the underlying mechanism.
לא ברורה לי שאלה. האם מדובר ב-AED - דפיברילטור אוטומטי? ידני? לצורך מה? איפה ימוקם? יש פרמטרים חשובים במעפיינים של דפיברילטורים חוץ מעוצמה - וכדאי לקחת בחשבון את כולם.
T4 ו T3 לא מזריקים נותנים כדורים המכילים T4 מצאתי מאמר אחד בו יש קשר בין לווטרים לרמות נמוכות שלFT4 בחלק מהמטופלים . התיעץ עם אנדוקרינולוג מבוגרים. זה לא האתר המתאים Seizure . 2017 May;48:7-10. doi: 10.1016/j.seizure.2017.03.011. Epub 2017 Mar 19. Effects of antiepileptic drugs on thyroid hormone function in epilepsy patients Fu-Yuan Shih 1, Yao-Chung Chuang 2, Ming-Jung Chuang 1, Yan-Ting Lu 3, Wan-Chen Tsai 3, Ting-Ying Fu 4, Meng-Han Tsai 5 Affiliations expand PMID: 28364656 DOI: 10.1016/j.seizure.2017.03.011 Abstract Purpose: Patients with epilepsy are frequently required to take antiepileptic drugs (AEDs) for a long period of time. Many studies have shown that AEDs have a negative influence on endocrine function including the thyroid gland, however the risk factors for the development of low thyroid function in these patients are unclear. This study aimed to determine the potential risk factors of low thyroid function in patients with epilepsy. Method: This was a cross-sectional study including 298 patients with epilepsy. Patients with previous thyroid disease were excluded. Epidemiologic data, type of epilepsy, etiology, the age of seizure onset, duration of epilepsy, intractable epilepsy, and number and dosage of AEDs were recorded. Levels of free thyroxine (fT4) and thyroid stimulating hormone (TSH) were measured. Results: Fifty-two of the 298 (17.4%) patients had low fT4. Older age (P=0.004), female sex (P=0.014), longer duration of epilepsy (P=0.001), and intractable epilepsy (P=0.009) were significantly associated with low fT4. Regarding individual AEDs, carbamazepine (30.1%), topiramate (28.6%), and levetiracetam (24.3%) were significantly associated with the presence of low fT4. After stepwise logistic regression of all significant variables, female sex, older age, three or more AEDs, and carbamazepine were independent risk factors for low fT4. Conclusions: Female patients with epilepsy and an older age, AED polytherapy, and carbamazepine treatment had a higher risk of low fT4. Thyroid function in these patients should be monitored closely. Keywords: Antiepileptic drugs; Epilepsy; Risk factor; Thyroid function.
יתכן ולתרופות אלו השפעה על איכות התנועה של הזרע להלן מאמר בנושא Effects of antiepileptic drugs on sperm motility of normal controls and epileptic patients with long-term therapy. AuthorsChen SS, et al. Show all Journal Epilepsia. 1992 Jan-Feb;33(1):149-53. Affiliation Department of Neurology, Kaohsiung Medical College, Taiwan, R.O.C. Abstract The in vitro effects of four antiepileptic drugs (AEDs) on human sperm motility were studied with a transmembrane migration method. Sperm motility of epileptic patients receiving chronic AED therapy was also investigated. Sperm motility was measured immediately after semen had been mixed with AED and after a 2-h preincubation at 37 degrees C. Both in vitro and in vivo studies demonstrated that AEDs inhibited sperm motility. When the drug effect was evaluated after the semen-AED mixture had been preincubated for 2 h, sperm motility was inhibited to 50% of control at concentrations of 1.59, 4.23, and 5.00 mM for phenytoin, carbamazepine, and valproate, respectively. Both with and without preincubation, phenobarbital, even up to 12.92 mM, did not inhibit the motility to less than 50% of the control. In the in vivo study, poor sperm motility was noted in epileptic patients with long-term AED therapy despite serum levels within the therapeutic range. Shorter duration of activity of spermatozoa was also observed in these patients. Interference with sperm membrane function by AEDs may be the underlying mechanism.
לגבי החלק השני של שאלתך "מד לחץ דם"-ראי דיון שכבר התקיים כאן שממנו תוכלי לקבל תשובות לשאלתך http://www.doctors.co.il/m/Doctors/a/Forums/xFF/Read/xFI/1178/xPG/7/xFT/3598/xFP/3598