מהו המנגנון בו פועלים שמני האומגה להורדת השומנים ?
דיון מתוך פורום ייעוץ תרופתי
The primary mechanism underlying the hypotriglyceridemic effect of Omacor AND other omega-3 PUFAs appears to be a reduction in hepatic production of triglycerides. Omega-3 PUFAs also decrease hepatic production of very low density lipoprotein (VLDL).
לתוהה שלום, המנגנון הינו מורכב ומכיל מספר דרכי פעולה, מצ"ב התיאור הפרקמולוגי מהעלון לתרופה של OMACOR (אומגה 3 EPD/DHA) "Omacor is active on the plasma lipids by lowering triglyceride levels as a result of a fall in VLDL (very low density lipoprotein), AND the substance is also active on haemostasis AND blood pressure. Omacor reduces the synthesis of triglycerides in the liver because EPA AND DHA are poor substrates for the enzymes responsible for triglyceride synthesis AND they inhibit esterification of other fatty acids. The increase in peroxisomes of β-oxidation of fatty acids in the liver also contributes to the fall in triglycerides, by reducing the quantity of free fatty acids available for their synthesis. The inhibition of this synthesis lowers VLDL. ." בברכה, איל